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Hydrochloric Acid → 2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate | HCID 59536870 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride | HCID 68646447 | — |
反応手順
Of the compound from Example 12A, 340 mg (1.02 mmol) were admixed at RT with 6.8 ml of a 4N solution of hydrogen chloride in dioxane, and stirred for 1 h. The reaction mixture was concentrated under reduced pressure and dried in an HV. This gave 274 mg (99% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202895B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-9f140f45327940efaf8114ff642eb124 |
| 出典メモ | uspto-grants-2012_06 |