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HRID 220633作成日:2026年10月27日

Hydrochloric Acid → 2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochloride

https://huagongshe.com/reaction/220633

反応式

関与物質

役割名称HCID仕込み量
反応物Hydrochloric AcidHCID 313—
反応物tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamateHCID 59536870—
溶媒1,4-DioxaneHCID 31275—
生成物2-Nitro-1-[3-(trifluoromethyl)phenyl]ethanamine hydrochlorideHCID 68646447—

反応手順

Of the compound from Example 12A, 340 mg (1.02 mmol) were admixed at RT with 6.8 ml of a 4N solution of hydrogen chloride in dioxane, and stirred for 1 h. The reaction mixture was concentrated under reduced pressure and dried in an HV. This gave 274 mg (99% of theory) of the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08202895B2
出典データセットuspto-grants-2012_06
ORD IDord-9f140f45327940efaf8114ff642eb124
出典メモuspto-grants-2012_06