tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate → tert-butyl N-{2-amino-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

HRID 220650ノート

反応式

HRID 220650 の反応式
[N+:1]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)([O-])=O.[H][H]>CO.[Ni]>[NH2:1][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1

参加物

5

反応物 2

HCID 59536870tert-Butyl {2-nitro-1-[3-(trifluoromethyl)phenyl]ethyl}carbamateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 43094068tert-butyl N-{2-amino-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Of the compound from Example 100A, 3.87 g (11.2 mmol) were hydrogenated in 230 ml of methanol with 5 ml of Raney nickel suspension (50% in water) at a hydrogen pressure of 3 bar for 3 h. The reaction mixture was filtered over celite and washed with methanol, and the filtrate was freed from the solvent on a rotary evaporator. The residue was dried in an HV. This gave 3.50 g (99% of theory) of the title compound.

後処理

  1. filtrationThe reaction mixture was filtered over celite
  2. washwashed with methanol
  3. customthe filtrate was freed from the solvent on a rotary evaporator
  4. customThe residue was dried in an HV

出典と根拠

ORDレコード
ord-207fbb455af04181a7de44d3972cf79d
出典データセット
uspto-grants-2012_06
特許番号
US08202895B2

反応ノート

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