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Methanamine, N-methoxy-, hydrochloride (1:1) → (+/-)-tert-butyl 1-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

HRID 2206566
ノート
印刷プレビュー

反応式

HRID 2206566 の反応式
CO[C:3](=[O:23])[CH:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[C:7]1[CH3:22])[CH3:5].Cl.[CH3:25][NH:26][O:27][CH3:28].C([Mg]Cl)(C)C>>[CH3:28][O:27][N:26]([CH3:25])[C:3](=[O:23])[CH:4]([N:6]1[C:10]2=[N:11][CH:12]=[CH:13][CH:14]=[C:9]2[C:8]([C:15]([O:17][C:18]([CH3:20])([CH3:21])[CH3:19])=[O:16])=[C:7]1[CH3:22])[CH3:5]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 117779095(+/-)-tert-butyl 1-(1-methoxy-1-oxopropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylateHCID 178418918HCID 178418918、化合物

生成物 1

HCID 117779094(+/-)-tert-butyl 1-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate収率 60.3%

反応条件

温度
0 °C

実験手順

To a 100 mL round-bottom flask was added (±)-tert-butyl 1-(1-methoxy-1-oxopropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (0.958 g, 3.01 mmol) and N,O-dimethylhydroxylamine hydrochloride (0.440 g, 4.51 mmol). The flask was vac/purged 3× with N2 then THF (17 mL) were added and the reaction was cooled to −40° C. isopropylmagnesium chloride (4.51 ml, 9.03 mmol) was added dropwise and the reaction was mixed at that temperature for 1 h then warmed to 0° C. for 1 h then quenched with 1N HCl, extracted with EtOAc. The org layer was washed with water then brine, dried over Na2SO4, filtered, concentrated, deposited onto silica gel with aid of DCM, and purified by CC using 25% EtOAc in Hex as eluent to provide (±)-tert-butyl 1-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (0.630 g, 60.3%). LRMS (M+H+) m/z: calcd 348.41. found 348.2.

後処理

  1. customThe flask was vac/purged 3× with N2
  2. additionTHF (17 mL) were added
  3. additionwas added dropwise
  4. additionthe reaction was mixed at that temperature for 1 h
  5. customthen quenched with 1N HCl
  6. extractionextracted with EtOAc
  7. washThe org layer was washed with water
  8. dry with materialbrine, dried over Na2SO4
  9. filtrationfiltered
  10. concentrationconcentrated
  11. custompurified by CC

出典と根拠

ORDレコード
ord-b33217acc7f24b3ead6e981281077d3a
出典データセット
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09371331B2

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート