1,4-Dioxane hydrochloride → (1S)-1-(Oxan-4-yl)ethan-1-amine

HRID 2206638ノート

反応式

HRID 2206638 の反応式
CC([S@]([NH:7][CH:8]([CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[CH3:9])=O)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[O:13]1[CH2:14][CH2:15][CH:10]([C@@H:8]([NH2:7])[CH3:9])[CH2:11][CH2:12]1

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 89739114HCID 89739114、化合物

生成物 1

HCID 67033300(1S)-1-(Oxan-4-yl)ethan-1-amine収率 150.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (R)-2-methyl-N-(1-(tetrahydro-2H-pyran-4-yl)ethyl)Propane-2-sulfinamide (1.2 g) in CH2Cl2 (4 mL) was added HCl-dioxane (4 mL) at 25° C. The reaction was stirred for 2 hrs. Then the mixture was concentrated in vacuo, diluted with water and washed with ethyl acetate to give crude (S)-1-(tetrahydro-2H-pyran-4-yl)ethanamine (1.0 g) as a yellow oil.

後処理

  1. concentrationThen the mixture was concentrated in vacuo
  2. additiondiluted with water
  3. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-673f8ea57a9545458ab02013c64bcabb
出典データセット
uspto-grants-2016_06
特許番号
US09371331B2

反応ノート

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