化工社化工社 化学情報印刷レポート · 研究参考用
Allyl bromide → 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Allyl bromide | HCID 7841 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Bromo-2-chloro-4-hydroxybenzonitrile | HCID 53330452 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile | HCID 86714036 | 65% |
反応手順
A mixture of compound 37 (20.5 g, 88.1 mmol), allyl bromide (11.2 mL, 132 mmol) and K2CO3 (24.4 g, 176 mmol) in acetone (440 mL) was stirred for 3 hours under reflux. The mixture was filtrated and concentrated in vacuo. The resultant was partitioned between EtOAc and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography to afford the product 38 (15.6 g, 65%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09371303B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-bdbbee18eaab4fd48597365336264816 |
| 出典メモ | uspto-grants-2016_06 |