化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → Methyl 2-amino-3-methoxybenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Benzoic acid, 3-methoxy-2-nitro-, methyl ester | HCID 79195 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 2-amino-3-methoxybenzoate | HCID 602320 | 99.7% |
反応手順
A suspension of compound 52 (26.2 g, 124 mmol) and Pd/C (10 wt. %, 6.0 g) in THF (400 mL) and MeOH (200 mL) was stirred under an atmosphere of H2 at room temperature for 18 hours. EtOAc (300 mL) was added to the mixture and filtered through a Celite pad. The filtrate was concentrated in vacuo to provide the crude product 53 (22.4 g, 99%) as colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09371303B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-f29ead4b9b4b443baed769dc2288e81c |
| 出典メモ | uspto-grants-2016_06 |