化工社化工社 化学情報印刷レポート · 研究参考用
Ethylene Glycol → 7-Bromo-4-chloro-2-methyl-2,3-dihydrobenzofuran-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | 4-(Allyloxy)-5-bromo-2-chlorobenzonitrile | HCID 86714036 | — |
| 生成物 | 7-Bromo-4-chloro-2-methyl-2,3-dihydrobenzofuran-5-carbonitrile | HCID 71076903 | 52% |
反応手順
The compound 38 (2.03 g, 7.45 mmol) in ethylene glycol (5 mL) was subjected to microwave conditions (Biotage®) at 250° C. for 90 min. The reaction mixture was cooled to r.t. and extracted with EtOAc/H2O (50 mL/100 mL). The organic layer was dried over MgSO4, filtered off, and evaporated in vacuo. The residue was purified using normal phase column chromatography to obtain the title product (1.05 g, 52%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09371303B2 |
| 出典データセット | uspto-grants-2016_06 |
| ORD ID | ord-22a188a88eb0429798d0ffe0eec7b1e9 |
| 出典メモ | uspto-grants-2016_06 |