Hydrochloric Acid → Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

HRID 220675ノート

反応式

HRID 220675 の反応式
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([CH:9]([NH:17]C(=O)OC(C)(C)C)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15])[CH:6]=[CH:7][CH:8]=1.[ClH:27]>ClCCl.O1CCOCC1>[ClH:27].[NH2:17][CH:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:26])[CH:4]=1)[CH2:10][NH:11][C:12](=[O:16])[O:13][CH2:14][CH3:15]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 59536750tert-Butyl ethyl {1-[3-(trifluoromethyl)phenyl]ethane-1,2-diyl}biscarbamate

生成物 1

HCID 86646633Ethyl {2-amino-2-[3-(trifluoromethyl)phenyl]ethyl}carbamate hydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

A solution of 527 mg (1.40 mmol) of the compound from Example 103A in 9.6 ml of dichloromethane was admixed at RT with 9.4 ml (37 mmol) of 4M hydrogen chloride in dioxane and stirred for 1 h. Then all of the volatile constituents were removed on a rotary evaporator. Drying of the residue in an HV gave 437 mg (94% of theory) of the title compound.

後処理

  1. customThen all of the volatile constituents were removed on a rotary evaporator
  2. customDrying of the residue in an HV

出典と根拠

ORDレコード
ord-ac6b2bf161ad426da7a1b50b363000e2
出典データセット
uspto-grants-2012_06
特許番号
US08202895B2

反応ノート

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