3,3,3-Trifluoro-1-phenylpropan-1-amine → HCID 59536817、化合物

HRID 220703ノート

反応式

HRID 220703 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C@H:14]([OH:19])[C:15]([F:18])([F:17])[F:16])[C:11](=[O:20])[N:10]([CH2:21][C:22](NC(C3C=CC=CC=3C)CCO)=[O:23])[N:9]=2)=[CH:4][CH:3]=1.[F:36][C:37]([F:48])([F:47])[CH2:38][CH:39]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[NH2:40]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C@H:14]([OH:19])[C:15]([F:17])([F:16])[F:18])[C:11](=[O:20])[N:10]([CH2:21][C:22]([NH:40][CH:39]([C:41]3[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH2:38][C:37]([F:47])([F:48])[F:36])=[O:23])[N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 178957523,3,3-Trifluoro-1-phenylpropan-1-amineHCID 595368572-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-[3-hydroxy-1-(2-methylphenyl)propyl]acetamide

生成物 1

HCID 59536817HCID 59536817、化合物

実験手順

In the same way as for the compound from Example 86, 50 mg (0.14 mmol) of the compound from Example 8A and 28 mg (0.15 mmol) of 3,3,3-trifluoro-1-phenylpropan-1-amine were reacted. This gave 44 mg (59% of theory) of the target compound.

出典と根拠

ORDレコード
ord-67523bdafdca4271bc28b9425d38bf67
出典データセット
uspto-grants-2012_06
特許番号
US08202895B2

反応ノート

読み込み中…