Benzyl Bromide → 2-[(3-Acetyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6-methoxy-tetralin-1-one bromide

反応式

[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH2:24]([Br:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Br-:31].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

参加物

反応物 2

HCID 7498Benzyl Bromide

HCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

生成物 1

HCID 1185580592-[(3-Acetyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6-methoxy-tetralin-1-one bromide

実験手順

The title compound 119 is prepared according to the procedure reported in Example 38.1 with compound 103 (67 mg, 0.2 mmol) and benzyl bromide as reactants. White solid. (Yield 34.5 mg, 80%).

出典と根拠

ORDレコード: ord-f5f7ce2042d84f28ba74695e36e7b4bd
出典データセット: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09376387B2

反応ノート

読み込み中…