Water → HCID 118558060、化合物

反応式

[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=2)[C:13]1=[O:24])(=[O:4])[CH3:3].C(NC(=O)C1CC=CNC=1)C1C=CC=CC=1.O>ClCCl>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22][CH3:23])[CH:18]=3)[C:13]2=[O:24])[CH:9]=[CH:8][N:7]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)[CH:6]=1)(=[O:4])[CH3:3]

参加物

実験手順

To a solution of pyridinium salt 131 (75 mg, 0.15 mmol) in dry and degassed dichloromethane (2.5 mL) was added at once N-benzyl-1,4-dihydronicotinamide (BNAH) (32 mg, 1 equiv) at 25° C. under Argon. The reaction was monitored by TLC until the starting material has disappeared (48 h). Then, water and dichloromethane were added. The organic layer was washed twice with water and once with brine, dried over magnesium sulfate and concentrated to dryness. The crude residue was purified by column chromatography (gradient of EtOAc in petroleum ether) to afford the title compound 153 as a yellow solid (Yield 29 mg, 44%).