Potassium Carbonate → HCID 58683810、化合物

HRID 220755

反応式

HRID 220755 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH:5]=[O:6].S([CH2:22][N+:23]#[C-:24])(C1C=CC(C)=CC=1)(=O)=O.C([O-])([O-])=O.[K+].[K+]>CO>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[O:6][CH:24]=[N:23][CH:22]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 986623-Bromo-4-methoxybenzaldehydeHCID 161915Tosylmethyl isocyanide

生成物 1

HCID 58683810HCID 58683810、化合物収率 80.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The mixed solution of 3-bromo-4-methoxybenzaldehyde (200 mg, 0.93 mmol) in methanol (4 mL) was added tosylmethyl isocyanide (200 mg, 1.02 mmol) and K2CO3 (260 mg, 1.88 mmol). The reaction was stirred at room temperature for 5 min before heated to 80° C. in the sealed tube. After 30 min, the solution was cooled to room temperature and concentrated. Column chromatography afforded 5-(3-bromo-4-methoxyphenyl)oxazole (o) (190 mg, 80%). Following the procedures analogous to the Suzuki and amide coupling reactions described for Compound 20, Compound 25 was prepared.

後処理

  1. temperaturebefore heated to 80° C. in the sealed tube
  2. waitAfter 30 min
  3. temperaturethe solution was cooled to room temperature
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-b408120d9c7e404abd0bb2bc574e6ca7
出典データセット
uspto-grants-2012_06
特許番号
US08202999B2

関連ノート

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