Benzoyl chloride → HCID 57555405、化合物

HRID 220811

反応式

HRID 220811 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].C(=O)(O)[O-].[Na+].[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CCOC(C)=O.O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:3]([OH:9])[CH:4]=1

参加物

6

反応物 3

HCID 7412Benzoyl chlorideHCID 915912-Amino-5-chlorophenolHCID 516892Sodium Bicarbonate

生成物 1

HCID 57555405HCID 57555405、化合物収率 82.8%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Amino-5-chlorophenol (1.45 g, 10 mmol) was dissolved in EtOAc (30 ml) and water (20 ml). Sodium bicarbonate (1.25 g, 15 mmol) then benzoyl chloride (1.42 g, 10 mmol) were added and the mixture was stirred at room temperature for 1 h. The layers were partitioned and the organic layer was washed with brine, dried and concentrated in vacuo. The residue was triturated with di-ethyl ether to yield the title compound (2.05 g, 82%).

後処理

  1. customThe layers were partitioned
  2. washthe organic layer was washed with brine
  3. customdried
  4. concentrationconcentrated in vacuo
  5. customThe residue was triturated with di-ethyl ether

出典と根拠

ORDレコード
ord-10d36463adb94f57853f5b42f12f0bdb
出典データセット
uspto-grants-2012_06
特許番号
US08202858B2

関連ノート

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