Benzoyl chloride → N-(4-chloro-2-hydroxyphenyl)benzamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].C(=O)(O)[O-].[Na+].[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CCOC(C)=O.O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:3]([OH:9])[CH:4]=1参加物
6
実験手順
2-Amino-5-chlorophenol (1.45 g, 10 mmol) was dissolved in EtOAc (30 ml) and water (20 ml). Sodium bicarbonate (1.25 g, 15 mmol) then benzoyl chloride (1.42 g, 10 mmol) were added and the mixture was stirred at room temperature for 1 h. The layers were partitioned and the organic layer was washed with brine, dried and concentrated in vacuo. The residue was triturated with di-ethyl ether to yield the title compound (2.05 g, 82%).
後処理
- customThe layers were partitioned
- washthe organic layer was washed with brine
- customdried
- concentrationconcentrated in vacuo
- customThe residue was triturated with di-ethyl ether
出典と根拠
- ORDレコード
- ord-10d36463adb94f57853f5b42f12f0bdb
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08202858B2
反応ノート
読み込み中…