Ethanol → Ethyl 3-fluoro-4-hydroxybenzoate

HRID 220817

反応式

HRID 220817 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([F:1])[CH:3]=1)[CH3:18]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1604563-Fluoro-4-hydroxybenzoic acid

生成物 1

HCID 13745619Ethyl 3-fluoro-4-hydroxybenzoate収率 85%

実験手順

A solution of 3-fluoro-4-hydroxy-benzoic acid (5.16 g, 33.1 mmol) in ethanol (100 ml) was treated with conc. sulphuric acid (5 ml), and the mixture heated at reflux for 4 days. The volatiles were removed in vacuo, and the aqueous residue was basified with saturated NaHCO3 and extracted twice with diethyl ether. The combined organic extracts were dried and concentrated in vacuo to yield the title compound (5.16 g, 85%).

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 4 days
  3. customThe volatiles were removed in vacuo
  4. extractionextracted twice with diethyl ether
  5. customThe combined organic extracts were dried
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9c84b9f0d9cf4aa3ae0ff39ecb8f6250
出典データセット
uspto-grants-2012_06
特許番号
US08202858B2

関連ノート

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