Acetyl chloride → Methyl 4-Amino-2-chlorobenzoate

HRID 220851

反応式

HRID 220851 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([Cl:11])[CH:3]=1.[C:12](Cl)(=O)C>CO>[CH3:12][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[CH:3][C:4]=1[Cl:11]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 171544-Amino-2-chlorobenzoic acid

生成物 1

HCID 11839197Methyl 4-Amino-2-chlorobenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-Amino-2-chloro-benzoic acid (5.3 g, 31 mmol) in methanol (100 ml) was treated with acetyl chloride (5 ml) and then heated at reflux for 16 hours. The solvents were evaporated in vacuo. The residue was dissolved in EtOAc, washed with saturated sodium hydrogen carbonate, dried and concentrated in vacuo to yield the title compound as a purple solid, 5.45 g, 95%.

後処理

  1. temperatureheated
  2. temperatureat reflux for 16 hours
  3. customThe solvents were evaporated in vacuo
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with saturated sodium hydrogen carbonate
  6. customdried
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-54db863b2afa414085e0648f08ae77ca
出典データセット
uspto-grants-2012_06
特許番号
US08202858B2

関連ノート

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