化工社化工社 化学情報印刷レポート · 研究参考用
5-Hydroxy-1-tetralone → oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Hydroxy-1-tetralone | HCID 119921 | — |
| 反応物 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 生成物 | oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone | HCID 86748747 | — |
反応手順
reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)-epichlorhydrine, in an aprotic solvent in the presence of a strong base at a temperature of over 90° C., to give the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone with an optical purity greater than 95%, and then,
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05426227 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-7d47044e2ac44991bb2f6c1fec64c091 |
| 出典メモ | uspto-grants-1995_06 |