Morpholine → Morpholine, 4-(2-methoxyethyl)-

HRID 2209329ノート

反応式

HRID 2209329 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH2:9][CH2:10]Cl>>[CH3:7][O:8][CH2:9][CH2:10][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 123162-Chloroethyl methyl ether

生成物 1

HCID 82460Morpholine, 4-(2-methoxyethyl)-

実験手順

In an autoclave of 100 mL, morpholine (45.0 g, 517 mmol) was made reacted with chloroethyl methyl ether (25.0 g, 265 mmol) at 130 deg C. for 48 hours. Solid salt that was formed was removed by filtration, and residue (filtrate) was subjected to reduced-pressure distillation by using a Vigreux column of 25 cm. Then 1H-NMR measurement of obtained amine is performed, and it was confirmed that chemical shifts, δ (ppm), are 3.53-3.55(m, 4H), 3.33-3.35(m, 2H), 3.17(s, 3H), and 2.36-2.32 (m, 6H), and that N-2-methoxyethylmorpholine was synthesized.

後処理

  1. customSolid salt that was formed
  2. customwas removed by filtration, and residue (filtrate)
  3. distillationwas subjected to reduced-pressure distillation

出典と根拠

ORDレコード
ord-569b4e245c044095ae2153b5d5a9beb1
出典データセット
uspto-grants-2016_06
特許番号
US09379413B2

反応ノート

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