ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Sulfuric Acid → (S)-2-(((Benzyloxy)carbonyl)amino)-5-((diphenyl(p-tolyl)methyl)amino)-5-oxopentanoic acid

HRID 2209860
ノート
印刷プレビュー

反応式

HRID 2209860 の反応式
[NH:1]([C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[CH3:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](O)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:24][CH:23]=1.C(OC(=O)C)(=O)C.S(=O)(=O)(O)O>C(O)(=O)C>[NH:1]([C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12])[C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH:6][C:28]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:25]1[CH:24]=[CH:23][C:22]([CH3:21])=[CH:27][CH:26]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 75855L-Glutamine, N2-[(phenylmethoxy)carbonyl]-HCID 951454-Methyltriphenylcarbinol

生成物 1

HCID 90470049(S)-2-(((Benzyloxy)carbonyl)amino)-5-((diphenyl(p-tolyl)methyl)amino)-5-oxopentanoic acid

試薬・触媒・溶媒 1

HCID 176
Acetic Acid
溶媒

実験手順

A mixture of 140.14 g Z-Gln-OH (0.5 mole) and 274.4 g 4-methyltriphenylcarbinol (1 mole) in 1.5 l acetic acid and 93.4 ml acetic anhydride (1 mole) is stirred at room temperature for 7 minutes. Upon addition of 2.5 ml concentrated sulfuric acid the temperature is raised to 50° C.; a clear, yellow solution results after 15 minutes. After 21/2 hrs the solution is allowed to cool and poured into 5 l ice-cold water. The precipitate formed is filtered off, washed thoroughly with water and dissolved in 1 l ethylacetate. The resulting solution is washed with saturated brine, dried over sodium sulfate and concentrated under reduced pressure to an oil (400 ml) which crystallized on addition of diisopropylether.

後処理

  1. temperatureis raised to 50° C.
  2. customa clear, yellow solution results after 15 minutes
  3. custom2 hrs
  4. temperatureto cool
  5. customThe precipitate formed
  6. filtrationis filtered off
  7. washwashed thoroughly with water
  8. dissolutiondissolved in 1 l ethylacetate
  9. washThe resulting solution is washed with saturated brine
  10. dry with materialdried over sodium sulfate
  11. concentrationconcentrated under reduced pressure to an oil (400 ml) which
  12. customcrystallized on addition of diisopropylether

出典と根拠

ORDレコード
ord-04c001aad7b0452e9625311106094da6
出典データセット
uspto-grants-1995_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05455363

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート