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1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene → 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochlorid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene | HCID 19079128 | — |
| 反応物 | Hydrochloride methanol | HCID 21893726 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochlorid | HCID 19079229 | 74.1% |
反応手順
To a solution of 840 mg (1.53 mmol) of 1,2-bis[N[4-(4-pyridylthio)butyl]-N-propionylamino]benzene in 20 ml of methanol, 80 ml of 10% hydrochloric acid/methanol was added, and the mixture was stirred for 30 minutes. The solvent was distilled off and the residue was recrystallized from ethanol/ether to give 707 mg of the desired product (74.1% yield, pale yellow crystals).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05457106 |
| 出典データセット | uspto-grants-1995_10 |
| ORD ID | ord-d331b9800f4549e0a97ba43f94aec973 |
| 出典メモ | uspto-grants-1995_10 |