Potassium Hydroxide → 5,6-Dihydro-4H-cyclopenta[c]furan-5-carboxylic acid
反応式
[C:1]([CH:6]1[CH2:13][C:9]2=[CH:10][O:11][CH:12]=[C:8]2[CH2:7]1)([O:3]CC)=[O:2].[OH-].[K+]>C(O)C.O>[C:1]([CH:6]1[CH2:13][C:9]2=[CH:10][O:11][CH:12]=[C:8]2[CH2:7]1)([OH:3])=[O:2]参加物
5
実験手順
Dissolve 5-(carboethoxy)-2,4,5,6-tetrahydro-cyclopenta[c]furan (6.2 g, 34.1 mmol) in ethanol (95%, 150 mL) and water (75 mL). Add potassium hydroxide (9.5 g, 0.17 mol) and stir at room temperature for 1 hour. Partition between water (150 mL) and ethyl ether (2×150 mL). Acidify the aqueous phase with hydrochloric acid to pH 1. Extract with methylene chloride (2×150 mL), dry (Na2SO4) and evaporate the solvent in vacuo to give 5-(carboxy)-2,4,5,6-tetrahydro-cyclopenta[c]furan.
後処理
- customPartition between water (150 mL) and ethyl ether (2×150 mL)
- extractionExtract with methylene chloride (2×150 mL)
- dry with materialdry (Na2SO4)
- customevaporate the solvent in vacuo
出典と根拠
- ORDレコード
- ord-f73761157d7e4e4ca63f33073e9e5038
- 出典データセット
- uspto-grants-1995_10
- 特許番号
- US05457196
反応ノート
読み込み中…