Benzyl (3-Oxopropyl)carbamate → ethyl P-(3-benzyloxycarbonylamino-1-hydroxy-propyl)-P-methyl-phosphinate
反応式
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH:14]=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][PH:17](=[O:21])[O:18][CH2:19][CH3:20]>C(N(CC)CC)C>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][CH:14]([P:17]([CH3:16])(=[O:21])[O:18][CH2:19][CH3:20])[OH:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of 5.18 g of 3-(benzyloxycarbonylamino)propionaldehyde, 2.7 g of ethyl P-methylphosphinate and 2,53 g of triethylamine is heated to 100° under an inert gas atmosphere for 2 hours. After cooling to room temperature the volatile materials are removed under reduced pressure to afford a viscous oil. Chromatography thereof on silica gel gives ethyl P-(3-benzyloxycarbonylamino-1-hydroxy-propyl)-P-methyl-phosphinate as a colourless, viscous oil.