2-Nitroaniline → Benzenemethanamine, 4-fluoro-N-(2-nitrophenyl)-

HRID 2210829ノート

反応式

HRID 2210829 の反応式
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])([O-:3])=[O:2].[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>C(C(C)=O)C>[F:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16][NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 69462-NitroanilineHCID 96024-Fluorobenzyl chloride

生成物 1

HCID 11311160Benzenemethanamine, 4-fluoro-N-(2-nitrophenyl)-

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

56 g N-(4-fluorobenzyl) 2-nitroaniline are reduced in the presence of 34 g of 5% palladized charcoal into methanol (560 ml) using a stream of hydrogen at room temperature and normal pression. After achievement of the reaction, the mixture is washed with nitrogen, filtered on clay (Trade Mark Celite) and concentrated to dryness. The residue is recrystallized from isopropyl ether. The desired N-substituted phenylene diamine, is thus obtained recovered weight: 38.5 g. The starting material N-(4-fluorobenzyl) 2-nitroaniline is prepared by alkylating the 2-nitroaniline by means of 4-fluorobenzyl chloride in the methyl ethyl ketone.

後処理

  1. customrecovered weight

出典と根拠

ORDレコード
ord-71b6a4a453dd4985aa36bbdea00cf675
出典データセット
uspto-grants-1995_10
特許番号
US05461059

反応ノート

読み込み中…