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Triethylamine → 1-(Methylthiomethyl)-6-phenylthiothymine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Chloromethyl methyl sulfide | HCID 16916 | — |
| 反応物 | 5-Methyl-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one | HCID 18671027 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(Methylthiomethyl)-6-phenylthiothymine | HCID 53840395 | 8.1% |
反応手順
To 4 ml of dimethylformamide, 0.17 ml (2.0 mmol) of chloromethylmethylsulfide, 0.47 g (2.0 mmol) of 6-phenylthiothymine, 0.56 ml (2.0 mmol) of triethylamine were added and allowed to react for 22 hours at room temperature. The reaction mixture was concentrated under reduced pressure and the residue was adsorbed on a silica gel column and eluted with chloroform. The eluate was concentrated and crystallized from ethyl acetate to obtain 45 mg of the target compound (Yield: 8%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05461060 |
| 出典データセット | uspto-grants-1995_10 |
| ORD ID | ord-5ca7112b5bda41a4b4713ca3e693ec49 |
| 出典メモ | uspto-grants-1995_10 |