Water → 2-(2-Decylindan-5-yl)-5-(3-phenylpropyloxy)pyrimidine

HRID 2211073ノート

反応式

HRID 2211073 の反応式
[CH2:1]([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[N:25]=[CH:24][C:23]([OH:26])=[CH:22][N:21]=3)[CH:17]=2)[CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].C1(C)C=CC(S(O[CH2:37][CH2:38][CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)(=O)=O)=CC=1.[OH-].[K+].O>C(O)C>[CH2:1]([CH:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]3[N:25]=[CH:24][C:23]([O:26][CH2:37][CH2:38][CH2:39][C:40]4[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=4)=[CH:22][N:21]=3)[CH:17]=2)[CH2:12]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

参加物

6

反応物 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 109899213-Phenylpropyl 4-methylbenzenesulfonateHCID 193753532-(2-Decylindan-5-yl)pyrimidine-5-ol

生成物 1

HCID 193753602-(2-Decylindan-5-yl)-5-(3-phenylpropyloxy)pyrimidine収率 56.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.443 g of 2-(2-decylindan-5-yl)pyrimidine-5-ol, 0.343 g of phenylpropyl p-toluenesulfonate and 0.1 g of potassium hydroxide were dissolved in 2 ml of ethanol, followed by heat-refluxing for 4 hours. After the reaction, the reaction mixture was poured into water and subjected to extraction with toluene. The resultant organic layer was washed with water and dried with anhydrous sodium sulfate, followed by distilling-off of the solvent and purification by silica gel column chromatography to obtain 0.313 g of an objective product (Yield: 53.2%).

後処理

  1. temperatureby heat-refluxing for 4 hours
  2. customAfter the reaction
  3. extractionsubjected to extraction with toluene
  4. washThe resultant organic layer was washed with water
  5. dry with materialdried with anhydrous sodium sulfate
  6. distillationfollowed by distilling-off of the solvent and purification by silica gel column chromatography

出典と根拠

ORDレコード
ord-7a8d88ac4e4845b1bd644afc12d679ed
出典データセット
uspto-grants-1995_10
特許番号
US05462694

反応ノート

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