Phosphorus oxychloride → 4-Chloro-7-phenyl-furano[2,3-d]pyridazine
反応式
[C:1]1([C:7]2[C:12]3[O:13][CH:14]=[CH:15][C:11]=3[C:10](=O)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:19])=O>ClC(Cl)C>[Cl:19][C:10]1[N:9]=[N:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[C:12]2[O:13][CH:14]=[CH:15][C:11]=12参加物
4
反応条件
- 温度
- 100 °C
実験手順
0.15 g of 7-phenyl-furano[2,3-d]pyridazine-4-(5H)-one and 10 ml of phosphorus oxychloride were dissolved in 10 ml of dichloroethane, and the solution was stirred at 100° C. for 3 hours. The reaction solution was concentrated, and a 1-N aqueous KOH solution was added thereto under cooling with ice. The solution was extracted with chloroform and dried. The solvent was distilled off, thereby obtaining 0.10 g of 4-chloro-7-phenyl-furano[2,3-d]pyridazine.
後処理
- concentrationThe reaction solution was concentrated
- additiona 1-N aqueous KOH solution was added
- temperatureunder cooling with ice
- extractionThe solution was extracted with chloroform
- customdried
- distillationThe solvent was distilled off
出典と根拠
- ORDレコード
- ord-eb7a79916817469fb9f2c585bcaa3f0e
- 出典データセット
- uspto-grants-1995_10
- 特許番号
- US05462941
反応ノート
読み込み中…