関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | Methyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate | HCID 200813 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-[(3-Trifluoromethylphenyl)amino]benzoic acid hydrazide | HCID 13167827 | 52% |
反応手順
Hydrazine hydrate (14 ml) is added dropwise to a solution of methyl 2-[(3-trifluoromethylphenyl)amino]-benzoate (1.463 g, 4.95 mmol) in 70 ml of methanol. The reaction solution is heated at 60° C. under an inert atmosphere for two hours and then concentrated in vacuo and chromatographed, eluting with ethyl acetate and hexane (1:1), providing 763.0 mg (52%) of a white solid, mp 134°-135° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05462952 |
|---|
| 出典データセット | uspto-grants-1995_10 |
|---|
| ORD ID | ord-ec0817b0d4fe4fb1959084b2d4b65fbf |
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| 出典メモ | uspto-grants-1995_10 |
|---|
