関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | ethyl 3-benzamido-1H-indole-2-carboxylate | HCID 2157323 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 3-Benzamidoindole-2-carboxamide | HCID 15284725 | — |
反応手順
A mixture of 3-Benzamido-2-carboethoxyindole (3.0 g) and phosphorous oxychloride (20 mL) was refluxed for 30 min. The reaction mixture was concentrated in vacuo and the residue was triturated with ether to afford a white solid. This solid was treated with 40 mL of isopropanol which had been previously saturated with ammonia and heated in a sealed tube at 120° C. for 40 min. The reaction mixture was again concentrated in vacuo and the residue was triturated with ether to afford 3-Benzamido-indole-2-carboxamide as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05463054 |
|---|
| 出典データセット | uspto-grants-1995_10 |
|---|
| ORD ID | ord-1ecde341c4ab414eb4b53fe74e156fa9 |
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| 出典メモ | uspto-grants-1995_10 |
|---|
