化工社化工社 化学情報印刷レポート · 研究参考用
p-Bromobenzenesulfonyl chloride → Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methyl 6-(2-aminoindan-5-yl)-6-(3-pyridyl)hex-5-enoate | HCID 54311386 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Methyl 6-(2-(4-bromobenzenesulphonylamino)indan-5-yl)-6-(3-pyridyl)hex-5-enoate | HCID 53803137 | — |
反応手順
3.4 g of methyl 6-(2-aminoindan-5-yl)-6-(3-pyridyl)hex-5-enoate is placed in 40 ml of chloroform together with 3.3 g of 4-bromobenzenesulphonic acid chloride and 1.8 g of triethylamine are added in batches at ambient temperature. After 30 minutes the solution is washed with water, dried and rotary evaporated. The yellow oil is then chromatographed over a silica gel column using cyclohexane/ethyl acetate (1:2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05426119 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-17636f13b32841d99940698ac3d7ea3d |
| 出典メモ | uspto-grants-1995_06 |