5-Phenylthiophene-2-carbaldehyde → 3-Bromo-2-fluoro-6-methyl-1-(5-phenyl-2-thienylmethyl)benzene

反応式

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[F:9].[C:10]1([C:16]2[S:20][C:19]([CH:21]=O)=[CH:18][CH:17]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:1][C:2]1[C:3]([F:9])=[C:4]([CH2:21][C:19]2[S:20][C:16]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:17][CH:18]=2)[C:5]([CH3:8])=[CH:6][CH:7]=1

参加物

反応物 2

HCID 1770535-Phenylthiophene-2-carbaldehyde

HCID 5732804-Bromo-3-fluorotoluene

生成物 1

HCID 666085273-Bromo-2-fluoro-6-methyl-1-(5-phenyl-2-thienylmethyl)benzene

実験手順

4-Bromo-3-fluorotoluene and 5-phenyl-2-thiophenecarboxaldehyde were treated in a manner similar to Reference Example 116 to give the target compound as pale blue powders. APCI-Mass m/Z 361/363 (M+H).

出典と根拠

ORDレコード: ord-5498241a5c344bbd98e509b40bdbbd3b
出典データセット: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08202984B2

反応ノート

読み込み中…