2-Tetralone → Naphthalene, 1,2-dihydro-3-methoxy-
反応式
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]1=[O:11].[CH:12]([O-])([O-])OC.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[CH3:12][O:11][C:2]1[CH2:3][CH2:4][C:5]2[C:10]([CH:1]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2参加物
5
実験手順
A mixture of 1.4 g of 2-tetralone, 1.5 mL of methyl orthoformate, and a few crystals of para-toluenesulfonic acid monohydrate in 75 mL of benzene was stirred for 22 hours and then evaporated in vacuo. The residue was chromatographed on Florisil® eluting with hexane/ethyl ether to provide 1.15 g (75%) of the desired title intermediate. NMR.
後処理
- customevaporated in vacuo
- customThe residue was chromatographed on Florisil®
- washeluting with hexane/ethyl ether
出典と根拠
- ORDレコード
- ord-e82e2fce827e40b7ad8e30cea3f679d0
- 出典データセット
- uspto-grants-1995_10
- 特許番号
- US05462954
反応ノート
読み込み中…