Hydrochloric Acid → HCID 67736902、化合物

HRID 2211408ノート

反応式

HRID 2211408 の反応式
[ClH:1].[C:2]1([C:8]2([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14](C(OC(C)(C)C)=O)[CH2:15]3)[C@:11]([F:32])([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[O:30][CH3:31])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1>[ClH:1].[C:33]1([C:8]2([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@:11]([F:32])([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[O:30][CH3:31])[CH2:10][CH2:9]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57167112HCID 57167112、化合物

生成物 1

HCID 67736902HCID 67736902、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of 6.3N hydrochloric acid in 20 cm3 of dioxane is added to a solution of 2.07 g of (3aS,4S,7aS)-7,7-diphenyl-4-fluoro-4-(2-methoxyphenyl)-2-tert-butoxycarbonyl-perhydroisoindole in 20 cm3 of dioxane at room temperature. The reaction mixture is stirred at this temperature for 3 hours and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallised in 40 cm3 of absolute ethanol and the crystals are filtered off and then dried. 1 g of (3aS,4S,7aS)-7,7-diphenyl-4-fluoro-4-(2-methoxyphenyl)-perhydroisoindole hydrochloride is obtained in the form of white crystals which melt at 270° C.

後処理

  1. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
  2. customThe residue is crystallised in 40 cm3 of absolute ethanol
  3. filtrationthe crystals are filtered off
  4. customdried

出典と根拠

ORDレコード
ord-c54366de8ab14a95bfabf28aeba768e7
出典データセット
uspto-grants-1995_10
特許番号
US05463077

反応ノート

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