2-(2-Nitrophenyl)ethyl p-toluenesulfonate → HCID 21963194、化合物
反応式
Cl.[N:2]1([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[S:10][N:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.S(C1C=CC(C)=CC=1)(O[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N+:29]([O-:31])=[O:30])(=O)=O>>[N+:29]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[CH2:22][CH2:21][N:5]1[CH2:6][CH2:7][N:2]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[S:10][N:9]=2)[CH2:3][CH2:4]1)([O-:31])=[O:30]参加物
3
実験手順
3-{4-[2-(2-Nitro-phenyl)-ethyl]-piperazin-1-yl}-1,2-benzisothiazole was prepared according to the general method as outlined in Preparation 2 starting with 3-piperazin-1-yl-benzoisothiazole hydrochloride (13.37 g, 52.4 mmol) and 2-nitrophenethyl tosylate (15.3 g, 47.7 mmol). The product was isolated via column chromatography to afford 13.08 g of a viscous, brown liquid. Yield 75%; MS (APCI): 369 [M+H]+.
後処理
- customThe product was isolated via column chromatography
- customto afford 13.08 g of a viscous, brown liquid