3-Methyl-2-butenoyl chloride → HCID 86591729、化合物
反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH2:24])[CH2:12][CH2:11]2)=[N:2]1.[CH3:25][C:26]([CH3:31])=[CH:27][C:28](Cl)=[O:29]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][C:28](=[O:29])[CH:27]=[C:26]([CH3:31])[CH3:25])[CH2:12][CH2:11]2)=[N:2]1参加物
3
実験手順
Starting from 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine (1 g, 2.82 mmol) and 3,3 dimethyl acryloyl chloride (0.33 mL, 2.97 mmol) and following the procedure as outlined in Example 1, 1.25 g of 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-amide was isolated as a white foam in 93% purity @ 214 nm; LCMS (APCI): 421 [M+H]+; mp 52° C.
出典と根拠
- ORDレコード
- ord-09fc629918ee4430816148d281f95930
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07101886B2