3-Methyl-2-butenoyl chloride → HCID 86591730、化合物

HRID 2211869

反応式

HRID 2211869 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=3[NH2:25])[CH2:12][CH2:11]2)=[N:2]1.[CH3:26][C:27]([CH3:32])=[CH:28][C:29](Cl)=[O:30]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=3[NH:25][C:29](=[O:30])[CH:28]=[C:27]([CH3:32])[CH3:26])[CH2:12][CH2:11]2)=[N:2]1

参加物

3

反応物 2

HCID 1023943-Methyl-2-butenoyl chlorideHCID 219632182-[2-(4-1,2-Benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenylamine

生成物 1

HCID 86591730HCID 86591730、化合物収率 77.9%

実験手順

Starting from 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenylamine (300 mg, 0.84 mmol) and 3,3 dimethyl acryloyl chloride (98 μL, 0.88 mmol) and following the procedure as outlined in Example 1, 287 mg of 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-amide was isolated as a white powder in 100% purity @ 254 nm; LCMS (APCI): 439 [M+H]+; mp 175° C.

出典と根拠

ORDレコード
ord-06e35ec3bb9c46d58936eb51c0735a92
出典データセット
uspto-grants-2006_09
特許番号
US07101886B2

関連ノート

読み込み中…