3-Methyl-2-butenoyl chloride → HCID 86594326、化合物
反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[NH:24][CH3:25])[CH2:12][CH2:11]2)=[N:2]1.[CH3:26][C:27]([CH3:32])=[CH:28][C:29](Cl)=[O:30]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[N:24]([CH3:25])[C:29](=[O:30])[CH:28]=[C:27]([CH3:32])[CH3:26])[CH2:12][CH2:11]2)=[N:2]1参加物
3
実験手順
Starting from {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-methyl-amine (300 mg, 0.84 mmol) and 3,3 dimethyl acryloyl chloride (97 μL, 0.88 mmol) and following the procedure as outlined in Example 1, 403 mg of 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenyl}-methyl-amide was isolated as a low melting solid in 100% purity @ 254 nm; LCMS (APCI): 435 [M+H]+.
出典と根拠
- ORDレコード
- ord-320f89d1d9184e1781bb518227b132a0
- 出典データセット
- uspto-grants-2006_09
- 特許番号