Ethyl trifluoroacetate → 2,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

HRID 2211971ノート

反応式

HRID 2211971 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH:3]([CH2:7][NH2:8])[CH2:2]1.C([O:11][C:12](=O)[C:13]([F:16])([F:15])[F:14])C>CO>[F:14][C:13]([F:16])([F:15])[C:12]([NH:8][CH2:7][CH:3]1[O:4][CH2:5][CH2:6][NH:1][CH2:2]1)=[O:11]

参加物

4

反応物 2

HCID 9794Ethyl trifluoroacetateHCID 45420271-(Morpholin-2-yl)methanamine

生成物 1

HCID 115502612,2,2-trifluoro-N-(morpholin-2-ylmethyl)acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
22 °C

実験手順

To a stirred solution of morpholin-2-ylmethylamine (3.1 g) in methanol (70 ml) under nitrogen was added an ethereal solution of ethyl-α,α,α-trifluoroacetate (5 ml in 20 ml ether) which had been washed with saturated aqueous sodium bicarbonate, water and brine, and dried. The mixture was stirred for 30 min at 22° C. before removal of all volatiles in vacuo. The residue was dissolved in methanol (10 ml) and the volatiles again removed in vacuo to give the title compound as a white crunchy foam (4.9 g).

後処理

  1. washhad been washed with saturated aqueous sodium bicarbonate, water and brine
  2. customdried
  3. dissolutionThe residue was dissolved in methanol (10 ml)
  4. customthe volatiles again removed in vacuo

出典と根拠

ORDレコード
ord-cd7c1072675e4c9dbc43dae231eba269
出典データセット
uspto-grants-2006_09
特許番号
US07101882B2

反応ノート

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