(4-Chlorophenyl)acetic acid → HCID 21962892、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:5][N:6]1[C:11]([CH3:13])([CH3:12])[CH2:10][O:9][CH:8]([CH2:14][NH2:15])[CH2:7]1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>CN1CCCC1=O>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:15][CH2:14][CH:8]2[O:9][CH2:10][C:11]([CH3:13])([CH3:12])[N:6]([CH2:5][C:4]3[CH:16]=[CH:17][C:18]([Cl:19])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:29])=[CH:23][CH:22]=1参加物
4
実験手順
A mixture of Intermediate 3 (0.030 g) and 4-chlorophenylacetic acid (0.020 g) were treated with 1-methyl-2-pyrrolidinone (0.015 ml) then heated in a 600 W microwave oven, at full power, for 4 min. The crude mixture was purified by chromatography on silica gel (Varian Bond-Elut cartridge, 1 g) eluting with cyclohexane/ethyl acetate (19:1 followed by 1:1) to give a brown solid which was triturated with ether to give thetitle compound as an off-white solid (0.018 g).