2-Fluoro-5-formylbenzonitrile → (E)-3-(3-Cyano-4-fluorophenyl)acrylic acid
反応式
CS(OC1C=CC(/C=[CH:13]/[C:14]([OH:16])=[O:15])=CC=1)(=O)=O.[F:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][C:19]=1[C:26]#[N:27].C(C1C=CC(OS(C)(=O)=O)=CC=1)=O>>[C:26]([C:19]1[CH:20]=[C:21](/[CH:22]=[CH:13]/[C:14]([OH:16])=[O:15])[CH:24]=[CH:25][C:18]=1[F:17])#[N:27]参加物
4
実験手順
5.52 g of (E)-3-(3-cyano-4-fluorophenyl)acrylic acid was synthesized as described for (E)-3-(4-(methanesulfonyloxy)phenyl)acrylic acid, using 4-fluoro-3-cyanobenzaldehyde (commercially available at Aldrich) instead of methanesulfonic acid 4-formylphenyl ester.
出典と根拠
- ORDレコード
- ord-fcc0565f987147498e1c1adca62d4f14
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07101898B2
反応ノート
読み込み中…