3-Bromo-2,5-difluoro-4-methoxybenzaldehyde → 3-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2,5-difluoro-4-methoxy-benzaldehyde

HRID 2212593

反応式

HRID 2212593 の反応式
Br[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:16])([CH3:15])[CH2:7][C:8](=[O:14])[N:9]2[CH2:12][CH3:13])=[CH:4][C:3]=1[CH3:17].Br[C:19]1[C:20]([F:30])=[C:21]([CH:24]=[C:25]([F:29])[C:26]=1[O:27][CH3:28])[CH:22]=[O:23]>>[CH2:12]([N:9]1[C:10]2[C:5](=[CH:4][C:3]([CH3:17])=[C:2]([C:19]3[C:20]([F:30])=[C:21]([CH:24]=[C:25]([F:29])[C:26]=3[O:27][CH3:28])[CH:22]=[O:23])[CH:11]=2)[C:6]([CH3:16])([CH3:15])[CH2:7][C:8]1=[O:14])[CH3:13]

参加物

3

反応物 2

HCID 219664313-Bromo-2,5-difluoro-4-methoxybenzaldehydeHCID 219664867-Bromo-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinolin-2-one

生成物 1

HCID 219664273-(1-Ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2,5-difluoro-4-methoxy-benzaldehyde収率 14%

実験手順

The intermediate 3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2,5-difluoro-4-methoxy-benzaldehyde was prepared in a similar manner to example 7a using 7-bromo-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinoline-2-one (example 2b) and 3-bromo-2,5-difluoro-4-methoxy benzaldehyde. 14% yield. 1H NMR (300 MHz; CDCl3): 1.21 (t, J=6.9 Hz, 3 H), 1.32 (s, 3 H), 1.33 (s, 3 H), 2.13 (s, 3 H), 2.53 (s, 2 H), 3.81 (2 s, 3 H), 4.02 (q, J=6.9 Hz, 1 H), 6.81 (s, 1 H), 7.23 (s, 1 H), 7.68 (dd, J1=6.3 Hz, J2=11.7 Hz, 1 H), 10.25 (2 s, 1 H).

出典と根拠

ORDレコード
ord-e3b32b9246c3489c9315700891f1ad91
出典データセット
uspto-grants-2006_09
特許番号
US07102000B2

関連ノート

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