Pyridiniumtribromide → 3-Bromo-2,5-difluoro-4-hydroxybenzaldehyde

HRID 2212594ノート

反応式

HRID 2212594 の反応式
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[C:7]([F:11])=[CH:6][C:3]=1[CH:4]=[O:5].[Br-:12].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>ClCCl>[Br:12][C:9]1[C:2]([F:1])=[C:3]([CH:6]=[C:7]([F:11])[C:8]=1[OH:10])[CH:4]=[O:5]

参加物

4

反応物 2

HCID 21124087PyridiniumtribromideHCID 219664622,5-Difluoro-4-hydroxybenzaldehyde

生成物 1

HCID 219664683-Bromo-2,5-difluoro-4-hydroxybenzaldehyde収率 86,169.102%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

To a solution of 2,5-difluoro-4-hydroxybenzaldehyde (37.5 g, 0.237 mmol) in dichloromethane (1.5 L) was added pyridinium tribromide (75.9 g, 0.237 mmol). The reaction mixture was stirred at 40° C. for 7 hrs then at room temperature overnight. The reaction was washed with water and brine, dried over magnesium sulfate, filtered and evaporated to give 48.4 g of crude 3-bromo-2,5-difluoro-4-hydroxybenzaldehyde use as this in the next step.

後処理

  1. customat room temperature
  2. customovernight
  3. washThe reaction was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-3b3a167c1c65433486f8a9691f5fee0a
出典データセット
uspto-grants-2006_09
特許番号
US07102000B2

反応ノート

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