Benzaldehyde → 7-Benzylidene-6,7-dihydro-5H-[1]pyrindine

HRID 2212814

反応式

HRID 2212814 の反応式
[N:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(OC(=O)C)(=O)C>>[CH:10](=[C:8]1[C:9]2[N:1]=[CH:2][CH:3]=[CH:4][C:5]=2[CH2:6][CH2:7]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 3

HCID 240BenzaldehydeHCID 7918Acetic AnhydrideHCID 68292Pyrindan

生成物 1

HCID 674163677-Benzylidene-6,7-dihydro-5H-[1]pyrindine収率 75%

実験手順

15 g (0.125 mol) of 6,7-dihydro-5H-[1]pyrindine, 20.1 g (0.19 mol) of freshly destilled benzaldehyde and 24.5 g (0.24 mol) of acetic acid anhydride were heated under reflux for 24 h. The reaction mixture was evaporated, the residual oil dissolved in methylene chloride, the solution extracted with 1N NaOH solution, and the organic phase dried and evaporated. The residue was destilled under reduced pressure to give 19.3 g (75%) of the title compound.

後処理

  1. temperatureunder reflux for 24 h
  2. customThe reaction mixture was evaporated
  3. dissolutionthe residual oil dissolved in methylene chloride
  4. extractionthe solution extracted with 1N NaOH solution
  5. customthe organic phase dried
  6. customevaporated

出典と根拠

ORDレコード
ord-b4246cd9d8eb40b4b6de6d466dbf1014
出典データセット
uspto-grants-2006_09
特許番号
US07105513B2

関連ノート

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