Hydrochloric Acid → 1-Oxa-8-azaspiro(4.5)decane hydrochloride
反応式
[ClH:1].[O:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1>CO>[ClH:1].[O:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3]1参加物
4
実験手順
Methanolic hydrogen chloride (3M, 20 mL) was added over 10 minutes to a stirred, cooled (0° C.) solution of 1,1-dimethylethyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (Description 74, 3.18 g, 13.2 mmol) in methanol (10 mL) and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to give the title compound (2.29 g, 98%). m/z (ES+) 142 (M+1).
後処理
- customThe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-c357045e74d94ad2a49741150c27557f
- 出典データセット
- uspto-grants-2006_09
- 特許番号
- US07105507B2
反応ノート
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