Hydrochloric Acid → 2-Oxa-8-azaspiro(4.5)decane

HRID 2213023ノート

反応式

HRID 2213023 の反応式
Cl.[CH2:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[CH2:5][CH2:4][O:3]1>CO>[CH2:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][O:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21955227Tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate

生成物 1

HCID 219552652-Oxa-8-azaspiro(4.5)decane収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methanolic hydrogen chloride (3M, 3 mL) was added to a stirred, cooled (0° C.) solution of 1,1-dimethylethyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate (Description 85, 150 mg, 0.62 mmol) in methanol and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure and the residue was dissolved in methanol and passed through Amberlyst 26 ion exchange resin, eluting with methanol. The solvent was evaporated under reduced pressure and the residue was dissolved in dichloromethane, dried (Na2SO4) and the solvent was evaporated under reduced pressure to give the title compound (77 mg, 88%). m/z (ES+) 142 (M+1).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in methanol
  3. washeluting with methanol
  4. customThe solvent was evaporated under reduced pressure
  5. dissolutionthe residue was dissolved in dichloromethane
  6. dry with materialdried (Na2SO4)
  7. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2ae52af1f26e4022a11cc74e74082482
出典データセット
uspto-grants-2006_09
特許番号
US07105507B2

反応ノート

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