Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 21956511、化合物

HRID 2213100ノート

反応式

HRID 2213100 の反応式
[CH2:1]([O:3][C:4](=[O:25])[CH:5]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:2].[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[CH:31]=O>C(Cl)Cl>[CH3:26][O:27][C:28]1[CH:29]=[C:30](/[CH:31]=[CH:5]/[C:4]([O:3][CH2:1][CH3:2])=[O:25])[CH:33]=[CH:34][C:35]=1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1

参加物

4

反応物 2

HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 219565123-Methoxy-4-pyridin-2-ylbenzaldehyde

生成物 1

HCID 21956511HCID 21956511、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Ethyl(triphenylphosphoranylidene)acetate (550 mg, 1.6 mmol) and 3-methoxy-4-pyridin-2-ylbenzaldehyde (225 mg, 1.1 mmol) were dissolved in CH2Cl2 (5 mL) and stirred at rt for 12 h. The reaction mixture was concentrated and purified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 2:3) to afford the desired ethyl(2E)-3-(3-methoxy-4-pyridin-2-ylphenyl)prop-2-enoate.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by flash column chromatography on silica gel eluting with EtOAc:hexanes (1:9 to 2:3)

出典と根拠

ORDレコード
ord-16d5cf6f80ba4be0810740c32e6b139d
出典データセット
uspto-grants-2006_09
特許番号
US07105533B2

反応ノート

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