Toluene → HCID 21957938、化合物

HRID 2213656ノート

反応式

HRID 2213656 の反応式
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18](C(C)C)=[CH:17][CH:16]=2)[CH:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:24]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH:33]([CH3:35])[CH3:34])[C:28]=1[N:36]=[C:37]=[O:38])([CH3:26])[CH3:25].[C:39]1(C)[CH:44]=CC=C[CH:40]=1>>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][N:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[CH:39]([CH3:44])[CH3:40])[C:37]([NH:36][C:28]2[C:29]([CH:33]([CH3:34])[CH3:35])=[CH:30][CH:31]=[CH:32][C:27]=2[CH:24]([CH3:25])[CH3:26])=[O:38])[CH:10]=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 1140TolueneHCID 922592,6-Diisopropylphenyl isocyanateHCID 21957926HCID 21957926、化合物

生成物 1

HCID 21957938HCID 21957938、化合物

実験手順

To a solution of [(1-benzylpyrazol-4-yl)methyl](4-isopropylphenyl)amine (0.17 g) in toluene (5 mL) was added 2,6-diisopropylphenyl isocyanate (0.12 mL) and the mixture was stirred overnight at room temperature. The reaction mixture was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to give N-[(1-benzylpyrazol-4-yl)methyl]-N′-(2,6-diisopropylphenyl)-N-(isopropylphenyl)urea (0.24 g).

後処理

  1. washThe reaction mixture was washed with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-ef089b70f1ce4cba833edbf8a9a8f553
出典データセット
uspto-grants-2006_09
特許番号
US07105567B2

反応ノート

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