Triethylamine → 4-(5-Pyridin-4-yl-[1,3,4]oxadiazol-2-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester

HRID 221373

反応式

C(N(CC)CC)C.[C:8]([O:12][C:13]([N:15]1[CH2:20][CH2:19][CH:18]([O:21][CH2:22][C:23](=O)[NH:24][NH:25][C:26]([C:28]2[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=2)=[O:27])[CH2:17][CH2:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>C(Cl)Cl>[C:8]([O:12][C:13]([N:15]1[CH2:20][CH2:19][CH:18]([O:21][CH2:22][C:23]2[O:27][C:26]([C:28]3[CH:33]=[CH:32][N:31]=[CH:30][CH:29]=3)=[N:25][N:24]=2)[CH2:17][CH2:16]1)=[O:14])([CH3:9])([CH3:11])[CH3:10]

参加物

実験手順

Triethylamine (149 μl, 1.06 mmol was added to stirred solution of 4-{2-oxo-2-[N′-(pyridine-4-carbonyl)hydrazino]ethoxy}piperidine-1-carboxylic acid tert-butyl ester (Preparation 16, 200 mg, 0.53 mmol) and 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate (147 mg, 0.53 mmol) in CH2Cl2 (10 ml). After 18 h at rt, the solvent was reduced to a small volume and this mixture purified by flash chromatography (EtOAc), affording the title compound: RT=3.42 min; m/z (ES+)=361.1 [M+H]+.

後処理

customthis mixture purified by flash chromatography (EtOAc)

出典と根拠

ORDレコード: ord-f3c522404ea4472aa7ae49be4fbede58
出典データセット: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08207147B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート