Water → 2',4'-Difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide

HRID 221391ノート

反応式

HRID 221391 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]=[CH2:26])[CH:20]=2)(=[O:17])=[O:16])=[CH:11][CH:10]=1.[OH2:27]>C(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:11][C:12]([S:15]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH:25]3[CH2:26][O:27]3)[CH:20]=2)(=[O:16])=[O:17])=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 962WaterHCID 673295122',4'-Difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide

生成物 1

HCID 866562622',4'-Difluoro-N-(3-(oxiran-2-yl)phenyl)biphenyl-4-sulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Dry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean, dry, uncontaminated vacuum desiccator for at least 48 hours; 3.7 g, 21 mmol) was added to a solution of 2′,4′-difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide (1.16 g, 4.3 mmol) in dry DCM (30 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 5 hours. Water (30 mL) was added and the layers were separated. The DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL) and dried over MgSO4. The solvent was evaporated and the title compound obtained as an orange oil (1.16 g) which was used without further purification.

後処理

  1. dry with materialDry meta-chloroperoxybenzoic acid (˜85%, dried over KOH in a clean,
  2. customdry
  3. waituncontaminated vacuum desiccator for at least 48 hours
  4. customthe layers were separated
  5. washThe DCM layer was washed with 10% Na2SO3 (30 mL), saturated NaHCO3 (30 mL), water (30 mL) and brine (30 mL)
  6. dry with materialdried over MgSO4
  7. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-b0b567b37f1345a59fe7ff70b1aa8a2b
出典データセット
uspto-grants-2012_06
特許番号
US08207167B2

反応ノート

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