m-Nitroacetophenone → 2-Bromo-1-(3-nitrophenyl)ethan-1-one

HRID 221399

反応式

HRID 221399 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br-:13].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(O)(=O)C>[Br:13][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:12]

参加物

4

反応物 2

HCID 8494m-NitroacetophenoneHCID 21124087Pyridiniumtribromide

生成物 1

HCID 752132-Bromo-1-(3-nitrophenyl)ethan-1-one収率 127.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

m-Nitroacetophenone (20 g) was dissolved in acetic acid (150 mL) under argon. Pyridinium tribromide (38.7 g) was added at once; the reaction was allowed to stir at room temperature for 1 hour and then quenched with water (250 mL). The product was filtered and air dried to give the title compound (25 g, 84%).

後処理

  1. customquenched with water (250 mL)
  2. filtrationThe product was filtered
  3. customair dried

出典と根拠

ORDレコード
ord-c14ea3eb512c47819ba451df036c0cd2
出典データセット
uspto-grants-2012_06
特許番号
US08207167B2

関連ノート

読み込み中…