Potassium Carbonate → Acetic acid, 2-(4-acetyl-2-methylphenoxy)-, methyl ester

HRID 2214

反応式

HRID 2214 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].Br[CH2:13][C:14]([O:16][CH3:17])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:8]([C:6]1[CH:5]=[CH:4][C:3]([O:11][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[C:2]([CH3:1])[CH:7]=1)(=[O:9])[CH3:10]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 701354'-Hydroxy-3'-methylacetophenone

生成物 1

HCID 19261664Acetic acid, 2-(4-acetyl-2-methylphenoxy)-, methyl ester

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 4-hydroxy-3-methylacetophenone (5 g), methyl bromoacetate (3.70 ml) and anhydrous potassium carbonate (5.52 g) in acetone (100 ml) was stirred for 66 hours. The mixture was filtered and the filtrate evaporated to give an oil which crystallised on standing giving methyl 4-acetyl-2-methylphenoxyacetate, 7.2 g: m.p. 51°-53° C.; NMR (d6DMSO) δ 7.79 (1H, s), 7.77 (1H, d), 6.94(1H,d), 4.93 (2H, s), 3.71 (3H, s), 2.50 (3H, s+DMSO), 2.24 (3H, s).

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customto give an oil which
  4. customcrystallised

出典と根拠

ORDレコード
ord-bee4694b03554b1caebf7d486567179e
出典データセット
uspto-grants-1998_03
特許番号
US05728701

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