2-(Dimethylamino)ethanol → HCID 69320189、化合物

HRID 2214310ノート

反応式

HRID 2214310 の反応式
[C:1]([Si:5]([CH3:38])([CH3:37])[O:6][C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[CH:24]([CH2:25][C:26]([OH:28])=[O:27])[O:23][C:22]4[CH:21]=[C:20]([O:29][Si:30]([C:33]([CH3:36])([CH3:35])[CH3:34])([CH3:32])[CH3:31])[CH:19]=[CH:18][C:17]=4[C:12]=3[CH2:13][O:14][C:15]=2[CH:16]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:39][N:40]([CH3:44])[CH2:41][CH2:42]O.CC(C)N=C=NC(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl>[CH3:39][N:40]([CH3:44])[CH2:41][CH2:42][O:27][C:26](=[O:28])[CH2:25][CH:24]1[C:11]2[C:10]3[CH:9]=[CH:8][C:7]([O:6][Si:5]([C:1]([CH3:2])([CH3:4])[CH3:3])([CH3:38])[CH3:37])=[CH:16][C:15]=3[O:14][CH2:13][C:12]=2[C:17]2[CH:18]=[CH:19][C:20]([O:29][Si:30]([C:33]([CH3:36])([CH3:35])[CH3:34])([CH3:31])[CH3:32])=[CH:21][C:22]=2[O:23]1

参加物

6

反応物 3

HCID 79022-(Dimethylamino)ethanolHCID 12734DiisopropylcarbodiimideHCID 21959303HCID 21959303、化合物

生成物 1

HCID 69320189HCID 69320189、化合物

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of [2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-yl]-acetic acid, the compound prepared as in Example 95 above, (56 mg, 0.1 mmol), 2-dimethylamino-ethanol (30 μL, 27 mg, 3.0 eq.), DIC (14 mg, 18 μL) and DMAP (12 mg) in DCM (2 mL) was stirred for 13 hours. The reaction mixture was then concentrated to yield [2,8-Bis-(tert-butyl-dimethyl-silyloxy)-5,11-dihydro-chromeno[4,3-c]chromen-5-yl]-acetic acid 2-dimethylamino-ethyl ester as a crude foam.

後処理

  1. concentrationThe reaction mixture was then concentrated

出典と根拠

ORDレコード
ord-6aa8ebe363f9483ca39fe7ae668d16e4
出典データセット
uspto-grants-2006_09
特許番号
US07105679B2

反応ノート

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